Publications


Neuronal Morphogenesis - Methods and Protocols


Kazuhito Toyooka (Editor & author)

Methods in Molecular Biology, Neuronal Morphogenesis - Methods and Protocols, Springer, 2024

DOI

The cytoplasmic localization of ADNP through 14-3-3 promotes sex-dependent neuronal morphogenesis, cortical connectivity, and calcium signaling


Sarah A. Bennison, Sara M. Blazejewski, Xiaonan Liu, Gal Hacohen-Kleiman, Shlomo Sragovich, Sofia Zoidou, Olga Touloumi, Nikolaos Grigoriadis, Illana Gozes, Kazuhito Toyo-oka

Molecular Psychiatry, vol. 28(5), 2023, pp. 1946-1959


Localization of activity-dependent neuroprotective protein (ADNP) in neurospheres


Sarah A. Bennison, Sara M. Blazejewski, Xiaonan Liu, Gal Hacohen-Kleiman, Shlomo Sragovich, Sofia Zoidou, Olga Touloumi, Nikolaos Grigoriadis, Illana Gozes, Kazuhito Toyo-oka

Molecular Psychiatry, vol. 28(5), 2023, p. 1829


KIFC1 regulates the trajectory of neuronal migration.


H. Muralidharan, Shrobona Guha, Kiran Madugula, Ankita Patil, Sarah A. Bennison, Xiaohuan Sun, K. Toyo-oka, P. Baas

Journal of Neuroscience, vol. 42(11), 2022, pp. 2149-2165


Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia during neurite initiation


Megan R. Radler, Xiaonan Liu, Megan Peng, Brenna Doyle, Kazuhito Toyo-Oka, Elias T. Spiliotis

Current Biology, 2022, In Press


Nuak kinase signaling in development and disease of the central nervous system


Sarah A. Bennison, Xiaonan Liu, Kazuhito Toyo-oka

Cellular Signaling, 2022, In Press


Rpsa Signaling Regulates Cortical Neuronal Morphogenesis via Its Ligand, PEDF, and Plasma Membrane Interaction Partner, Itga6.


Sara M. Blazejewski, Sarah A. Bennison, Ngoc T. Ha, Xiaonan Liu, Trevor H. Smith, K. Dougherty, K. Toyo-oka

Cerebral cortex, vol. 32(4), 2022, pp. 770-795


TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunity.


W. Fu, Wenhuo Hu, Young-Su Yi, A. Hettinghouse, Guodong Sun, Yufei Bi, Wenjun He, Lei Zhang, G. Gao, Jody Liu, K. Toyo-oka, G. Xiao, D. Solit, P. Loke, Chuan-ju Liu

The Journal of clinical investigation, vol. 131(16), 2021


Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond Pafah1b1(Lis1), Crk and Ywhae(14-3-3ε)


Xiaonan Liu, Sarah A Bennison, Lozen Robinson, Kazuhito Toyo-Oka

Brain Sciences, vol. 12(1), 2021, p. 56


Glutathione S-transferase Pi (Gstp) Proteins Regulate Neuritogenesis in the Developing Cerebral Cortex.


Xiaonan Liu, Sara M. Blazejewski, Sarah A. Bennison, K. Toyo-oka

Human molecular genetics, vol. 30(1), 2021, pp. 30-45


Protein kinases: master regulators of neuritogenesis and therapeutic targets for axon regeneration


Sarah A. Bennison, Sara M. Blazejewski, Trevor H. Smith, K. Toyo-oka

Cellular and Molecular Life Sciences, vol. 77(8), 2019, pp. 1511-1530


Neurodevelopmental Genetic Diseases Associated With Microdeletions and Microduplications of Chromosome 17p13.3


Sara M. Blazejewski, Sarah A. Bennison, Trevor H. Smith, K. Toyo-oka

Front. Genet., vol. 9, 2018, p. 80


Methionine sulfoxide reductase A (MsrA) mediates the ubiquitination of 14‐3‐3 protein isotypes in brain


Yue Deng, Beichen Jiang, Carolyn L Rankin, K. Toyo-oka, M. Richter, J. Maupin-Furlow, J. Moskovitz

Free radical biology & medicine, vol. 129, 2018, pp. 600-607


Complete ablation of the 14-3-3epsilon protein results in multiple defects in neuropsychiatric behaviors


T. Wachi, Brett Cornell, K. Toyo-oka

Behavioural Brain Research, vol. 319, 2017, pp. 31-36


Overexpression of the 14-3-3gamma protein in embryonic mice results in neuronal migration delay in the developing cerebral cortex


Brett Cornell, T. Wachi, V. Zhukarev, K. Toyo-oka

Neuroscience Letters, vol. 628, 2016, pp. 40-46


Regulation of neuronal morphogenesis by 14-3-3epsilon (Ywhae) via the microtubule binding protein, doublecortin.


Brett Cornell, T. Wachi, V. Zhukarev, K. Toyo-oka

Human molecular genetics, vol. 25(10), 2016, pp. 4405-4418


Ablation of the 14‐3‐3gamma Protein Results in Neuronal Migration Delay and Morphological Defects in the Developing Cerebral Cortex


T. Wachi, Brett Cornell, C. Marshall, V. Zhukarev, P. Baas, K. Toyo-oka

Developmental neurobiology, vol. 76(6), 2016, pp. 600-614


14-3-3ε and ζ Regulate Neurogenesis and Differentiation of Neuronal Progenitor Cells in the Developing Brain


K. Toyo-oka, T. Wachi, Robert F Hunt, S. Baraban, S. Taya, H. Ramshaw, K. Kaibuchi, Q. Schwarz, Angel F. Lopez, A. Wynshaw-Boris

The Journal of Neuroscience, vol. 34(36), 2014, pp. 12168-12181


14-3-3ε Plays a Role in Cardiac Ventricular Compaction by Regulating the Cardiomyocyte Cell Cycle


Y. Kosaka, K. Cieslik, Ling Li, G. Lezin, C. Maguire, Y. Saijoh, K. Toyo-oka, M. Gambello, M. Vatta, A. Wynshaw-Boris, A. Baldini, H. Yost, Luca Brunelli

Molecular and Cellular Biology, vol. 32(24), 2012, pp. 5089-5102


Neuroepithelial Stem Cell Proliferation Requires LIS1 for Precise Spindle Orientation and Symmetric Division


J. Yingling, Y. Youn, D. Darling, K. Toyo-oka, T. Pramparo, S. Hirotsune, A. Wynshaw-Boris

Cell, vol. 132(3), 2008, pp. 474-486


Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation


K. Toyo-oka, D. Mori, Y. Yano, M. Shiota, H. Iwao, H. Goto, M. Inagaki, N. Hiraiwa, M. Muramatsu, A. Wynshaw-Boris, A. Yoshiki, S. Hirotsune

The Journal of cell biology, vol. 180(6), 2008, pp. 1133-1147


Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia.


M. Ikeda, T. Hikita, S. Taya, Junko Uraguchi-Asaki, K. Toyo-oka, A. Wynshaw-Boris, H. Ujike, T. Inada, K. Takao, T. Miyakawa, N. Ozaki, K. Kaibuchi, N. Iwata

Human molecular genetics, vol. 17(20), 2008, pp. 3212-3222


NDEL1 Phosphorylation by Aurora-A Kinase Is Essential for Centrosomal Maturation, Separation, and TACC3 Recruitment


D. Mori, Y. Yano, K. Toyo-oka, Noriyuki Yoshida, Masami Yamada, M. Muramatsu, Dongwei Zhang, H. Saya, Y. Toyoshima, K. Kinoshita, A. Wynshaw-Boris, S. Hirotsune

Molecular and Cellular Biology, vol. 27(1), 2006, pp. 352-367


Erratum: Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of Myc overexpression (Cancer Research (June 1, 2006) 66 (5565-5573))


K. Toyo-oka, T. J. Bowen, S. Hirotsune, Zirong Li, Sonia Jain, S. Ota, L. Escoubet-Lozach, Ivan Garcia-Bassets, J. Lozach, M. Rosenfeld, C. Glass, R. Eisenman, Bing Ren, P. Hurlin, A. Wynshaw-Boris

2006


Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression.


K. Toyo-oka, T. J. Bowen, S. Hirotsune, Zirong Li, Sonia Jain, S. Ota, L. Escoubet-Lozach, Ivan Garcia-Bassets, J. Lozach, M. Rosenfeld, C. Glass, R. Eisenman, Bing Ren, P. Hurlin, A. Wynshaw-Boris

Cancer research, vol. 66(11), 2006, pp. 5565-5573


Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.


K. Toyo-oka, Shinji Sasaki, Y. Yano, D. Mori, Takuya Kobayashi, Y. Toyoshima, Suzumi M. Tokuoka, S. Ishii, Takao Shimizu, M. Muramatsu, N. Hiraiwa, A. Yoshiki, A. Wynshaw-Boris, S. Hirotsune

Human molecular genetics, vol. 14(21), 2005, pp. 3113-3128


Complete Loss of Ndel1 Results in Neuronal Migration Defects and Early Embryonic Lethality


Shinji Sasaki, D. Mori, K. Toyo-oka, Amy Chen, L. Garrett-Beal, M. Muramatsu, S. Miyagawa, N. Hiraiwa, A. Yoshiki, A. Wynshaw-Boris, S. Hirotsune

Molecular and Cellular Biology, vol. 25(17), 2005, pp. 7812-7827


Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome.


K. Toyo-oka, S. Hirotsune, M. Gambello, Zi-Qiang Zhou, Lorin E. Olson, M. Rosenfeld, R. Eisenman, P. Hurlin, A. Wynshaw-Boris

Human molecular genetics, vol. 13(10), 2004, pp. 1057-1067


Evidence of Mnt-Myc Antagonism Revealed by Mnt Gene Deletion


P. Hurlin, Zi-Qiang Zhou, K. Toyo-oka, S. Ota, William L Walker, S. Hirotsune, A. Wynshaw-Boris

Cell cycle, vol. 3(2), 2004, pp. 95-97


Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.


C. Cardoso, R. Leventer, Heather L Ward, K. Toyo-oka, June Chung, A. Gross, C. Martin, J. Allanson, D. Pilz, A. Olney, O. Mutchinick, S. Hirotsune, A. Wynshaw-Boris, W. Dobyns, D. Ledbetter

American journal of human genetics, vol. 72(4), 2003, pp. 918-930


Miller-Dieker syndrome: analysis of a human contiguous gene syndrome in the mouse.


J. Yingling, K. Toyo-oka, A. Wynshaw-Boris

American journal of human genetics, vol. 73(3), 2003, pp. 475-488


14-3-3ε is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller–Dieker syndrome


K. Toyo-oka, Aki Shionoya, M. Gambello, C. Cardoso, R. Leventer, Heather L Ward, Ramsés Ayala, L. Tsai, W. Dobyns, D. Ledbetter, S. Hirotsune, A. Wynshaw-Boris

Nature Genetics, vol. 34(3), 2003, pp. 274-285


Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis


P. Hurlin, Zi-Qiang Zhou, K. Toyo-oka, S. Ota, William L Walker, S. Hirotsune, A. Wynshaw-Boris

The EMBO journal, vol. 22(18), 2003, pp. 4584-4596


Reversible CD8 expression induced by common cytokine receptor γ chain-dependent cytokines in a cloned CD4+ Th1 cell line


C. Park, Yi-fu Yang, Xuyu Zhou, K. Toyo-oka, Y. Yashiro‐Ohtani, W. Park, M. Tomura, X. Tai, T. Hamaoka, H. Fujiwara

2002


Reversible CD8 expression induced by common cytokine receptor gamma chain-dependent cytokines in a cloned CD4(+) T(h)1 cell line.


C. Park, Yi-fu Yang, Xuyu Zhou, K. Toyooka, Y. Yashiro‐Ohtani, W. Park, M. Tomura, X. Tai, T. Hamaoka, H. Fujiwara

International immunology, 2002


Functional annotation of a full-length mouse cDNA collection


J. Kawai, A. Shinagawa, K. Shibata, M. Yoshino, M. Itoh, Y. Ishii, T. Arakawa, A. Hara, Y. Fukunishi, H. Konno, J. Adachi, S. Fukuda, K. Aizawa, M. Izawa, K. Nishi, H. Kiyosawa, S. Kondo, I. Yamanaka, T. Saito, Y. Okazaki, T. Gojobori, H. Bono, T. Kasukawa, R. Saito, K. Kadota, H. Matsuda, M. Ashburner, S. Batalov, T. Casavant, W. Fleischmann, T. Gaasterland, C. Gissi, B. King, H. Kochiwa, P. Kuehl, S. Lewis, Y. Matsuo, I. Nikaido, G. Pesole, John Quackenbush, L. Schriml, F. Staubli, R. Suzuki, M. Tomita, L. Wagner, T. Washio, K. Sakai, T. Okido, M. Furuno, H. Aono, R. Baldarelli, G. Barsh, J. Blake, D. Boffelli, N. Bojunga, Piero Carninci, M. Bonaldo, M. Brownstein, C. Bult, C. Fletcher, M. Fujita, M. Gariboldi, S. Gustincich, D. Hill, M. Hofmann, D. Hume, M. Kamiya, N. Lee, P. Lyons, L. Marchionni, J. Mashima, J. Mazzarelli, P. Mombaerts, P. Nordone, B. Ring, M. Ringwald, I. Rodriguez, N. Sakamoto, H. Sasaki, K. Sato, C. Schönbach, T. Seya, Y. Shibata, Kai-Florian Storch, H. Suzuki, K. Toyo-oka, K. H. Wang, C. Weitz, C. Whittaker, L. Wilming, A. Wynshaw-Boris, K. Yoshida, Y. Hasegawa, H. Kawaji, S. Kohtsuki, Y. Hayashizaki

Nature, vol. 409(6821), 2001, pp. 685-690


TBX1 Is Responsible for Cardiovascular Defects in Velo-Cardio-Facial/DiGeorge Syndrome


S. Merscher, B. Funke, J. Epstein, J. Heyer, A. Puech, M. Lu, R. Xavier, M. Demay, R. Russell, S. Factor, Kazuhito Tokooya, B. S. Jore, M. Lopez, R. Pandita, M. Lia, D. Carrión, Hui Xu, H. Schorle, J. Kobler, P. Scambler, A. Wynshaw-Boris, A. Skoultchi, B. Morrow, R. Kucherlapati

Cell, vol. 104(4), 2001, pp. 619-629


Rafts by Enhancing the Association of TCR with in T Cell Rafts Induce T Cell Costimulation Non-CD28 Costimulatory Molecules Present


Y. Yashiro‐Ohtani, Xuyu Zhou, K. Toyo-oka, X. Tai, C. Park, T. Hamaoka, R. Abe, K. Miyake, H. Fujiwara

2000


Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts1


Y. Yashiro‐Ohtani, Xuyu Zhou, K. Toyo-oka, X. Tai, C. Park, T. Hamaoka, R. Abe, K. Miyake, H. Fujiwara

The Journal of Immunology, 2000


Association of a tetraspanin CD9 with CD5 on the T cell surface: role of particular transmembrane domains in the association.


K. Toyo-oka, Y. Yashiro‐Ohtani, C. S. Park, X. Tai, K. Miyake, T. Hamaoka, H. Fujiwara

International immunology, 1999


Differential involvement of a Fas-CPP32-like protease pathway in apoptosis of TCR/CD9-costimulated, naive T cells and TCR-restimulated, activated T cells.


C. S. Park, Y. Yashiro, X. Tai, K. Toyo-oka, T. Hamaoka, H. Yagita, K. Okumura, S. Neben, H. Fujiwara

Journal of immunology, 1998


A fundamental difference in the capacity to induce proliferation of naive T cells between CD28 and other co‐stimulatory molecules


Y. Yashiro, X. Tai, K. Toyo-oka, C. S. Park, R. Abe, T. Hamaoka, M. Kobayashi, S. Neben, H. Fujiwara

European journal of immunology, 1998


Synergy between CD28 and CD9 costimulation for naive T-cell activation.


K. Toyo-oka, X. Tai, Y. Yashiro, H. Ahn, R. Abe, T. Hamaoka, M. Kobayashi, S. Neben, H. Fujiwara

Immunology letters, 1997


CD9-mediated costimulation of TCR-triggered naive T cells leads to activation followed by apoptosis.


X. Tai, K. Toyooka, Y. Yashiro, R. Abe, C. S. Park, T. Hamaoka, M. Kobayashi, S. Neben, H. Fujiwara

Journal of immunology, 1997


CD28 co-stimulatory signals induce IL-2 receptor expression on antigen-stimulated virgin T cells by an IL-2-independent mechanism.


K. Toyooka, S. Maruo, T. Iwahori, N. Yamamoto, X. Tai, R. Abe, Y. Takahama, M. Murakami, T. Uede, T. Hamaoka, H. Fujiwara

International immunology, 1996


IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones.


S. Maruo, K. Toyo-oka, M. Oh‐hora, X. Tai, H. Iwata, H. Takenaka, S. Yamada, S. Ono, T. Hamaoka, M. Kobayashi, M. Wysocka, G. Trinchieri, H. Fujiwara

Journal of immunology, 1996


CD28 co-stimulatory signals induced IL-2 receptor expression on antigen-stimulated virgin T cells by an IL-2- independent mechanism.


Toyooka Kazuhito, Maruo Seiji, Iwahori Tohru, Yamamoto Norihiko, Tai Xu-Guang, Abe Ryo, Takahama Yousuke, Murakami Masaaki, Uede Toshimitsu, Hamaoka Toshiyuki, Fujiwara Hiromi

1996


A role for CD9 molecules in T cell activation


X. Tai, Y. Yashiro, R. Abe, K. Toyooka, C. Wood, J. Morris, A. Long, S. Ono, M. Kobayashi, T. Hamaoka, S. Neben, H. Fujiwara

The Journal of experimental medicine, 1996


Suppression of allograft responses by combining alloantigen-specific i.v. presensitization with suboptimal doses of FK 506 or rapamycin.


H. Iwata, T. Nagano, K. Toyo-oka, H. Hirose, T. Hamaoka, H. Fujiwara

Transplantation proceedings, 1994


Suppression of allograft responses by combining alloantigen-specific i.v. pre-sensitization with suboptimal doses of rapamycin.


H. Iwata, T. Nagano, K. Toyo-oka, H. Hirose, T. Hamaoka, H. Fujiwara

International immunology, 1994





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