APA
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Ikeda, M., Hikita, T., Taya, S., Uraguchi-Asaki, J., Toyo-oka, K., Wynshaw-Boris, A., … Iwata, N. (2008). Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Human Molecular Genetics, 17(20), 3212–3222.
Chicago/Turabian
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Ikeda, M., T. Hikita, S. Taya, Junko Uraguchi-Asaki, K. Toyo-oka, A. Wynshaw-Boris, H. Ujike, et al. “Identification of YWHAE, a Gene Encoding 14-3-3epsilon, as a Possible Susceptibility Gene for Schizophrenia.” Human molecular genetics 17, no. 20 (2008): 3212–3222.
MLA
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Ikeda, M., et al. “Identification of YWHAE, a Gene Encoding 14-3-3epsilon, as a Possible Susceptibility Gene for Schizophrenia.” Human Molecular Genetics, vol. 17, no. 20, 2008, pp. 3212–22.
BibTeX Click to copy
@article{m2008a,
title = {Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia.},
year = {2008},
issue = {20},
journal = {Human molecular genetics},
pages = {3212-3222},
volume = {17},
author = {Ikeda, M. and Hikita, T. and Taya, S. and Uraguchi-Asaki, Junko and Toyo-oka, K. and Wynshaw-Boris, A. and Ujike, H. and Inada, T. and Takao, K. and Miyakawa, T. and Ozaki, N. and Kaibuchi, K. and Iwata, N.}
}
Schizophrenia is a complex mental disorder with a fairly high degree of heritability. Although the causes of schizophrenia remain unclear, it is now widely accepted that it is a neurodevelopmental and neurodegenerative disorder involving disconnectivity and disorder of the synapses. Disrupted-in-schizophrenia 1 (DISC1) is a promising candidate susceptibility gene involved in neurodevelopment, including maturation of the cerebral cortex. To identify other susceptibility genes for schizophrenia, we screened for DISC1-interacting molecules [NudE-like (NUDEL), Lissencephaly-1 (LIS1), 14-3-3epsilon (YWHAE), growth factor receptor bound protein 2 (GRB2) and Kinesin family 5A of Kinesen1 (KIF5A)], assessing a total of 25 tagging single-nucleotide polymorphisms (SNPs) in a Japanese population. We identified a YWHAE SNP (rs28365859) that showed a highly significant difference between case and control samples, with higher minor allele frequencies in controls (P(allele) = 1.01 x 10(-5) and P(genotype) = 4.08 x 10(-5) in 1429 cases and 1728 controls). Both messenger RNA transcription and protein expression of 14-3-3epsilon were also increased in the lymphocytes of healthy control subjects harboring heterozygous and homozygous minor alleles compared with homozygous major allele subjects. To further investigate a potential role for YWHAE in schizophrenia, we studied Ywhae(+/-) mice in which the level of 14-3-3epsilon protein is reduced to 50% of that in wild-type littermates. These mice displayed weak defects in working memory in the eight-arm radial maze and moderately enhanced anxiety-like behavior in the elevated plus-maze. Our results suggest that YWHAE is a possible susceptibility gene that functions protectively in schizophrenia.