Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects

Journal article

Brett Cornell, K. Toyo-oka
BMC Research Notes, vol. 9(1), 2016, pp. 1-6

Semantic Scholar DOI PubMedCentral PubMed

Cite

APA Click to copy
Cornell, B., & Toyo-oka, K. (2016). Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects. BMC Research Notes, 9(1), 1–6.

Chicago/Turabian Click to copy
Cornell, Brett, and K. Toyo-oka. “Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 Promoter-Driven Cre Recombinase Results in Pigmentation Defects.” BMC Research Notes 9, no. 1 (2016): 1–6.

MLA Click to copy
Cornell, Brett, and K. Toyo-oka. “Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 Promoter-Driven Cre Recombinase Results in Pigmentation Defects.” BMC Research Notes, vol. 9, no. 1, 2016, pp. 1–6.

BibTeX Click to copy

@article{brett2016a,
  title = {Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects},
  year = {2016},
  issue = {1},
  journal = {BMC Research Notes},
  pages = {1-6},
  volume = {9},
  author = {Cornell, Brett and Toyo-oka, K.}
}

Abstract

BackgroundThe seven 14-3-3 protein isoforms bind to numerous proteins and are involved in a wide variety of cellular events, including the cell cycle, cell division, apoptosis and cancer. We previously found the importance of 14-3-3 proteins in neuronal migration of pyramidal neurons in the developing cortex. Here, we test the function of 14-3-3 proteins in the development of neural crest cells in vivo using mouse genetic approaches.ResultsWe found that 14-3-3 proteins are important for the development of neural crest cells, in particular for the pigmentation of the fur on the ventral region of mice.ConclusionsOur data obtained from the 14-3-3ε/14-3-3ζ/Wnt1-Cre mice strongly indicate the importance of 14-3-3 proteins in the development of melanocyte lineages.