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******* Attention *******
We are seeking lab members, including PhD and MS candidates as well as any other positions. If you are interested in our research project, feel free to contact me (Kazuhito Toyooka at Contact Form or [email protected]).
Thank you for visiting the website of the Toyooka Lab at Drexel University College of Medicine in Philadelphia.
Our team studies the molecular and cellular mechanisms underlying healthy cortical development. Current research focuses on identifying the etiology of neurodevelopmental disorders, such as autism spectrum disorder (ASD) and 17p13.3 deletion/duplication syndromes, as well as neurodegenerative diseases, such as Parkinson's Disease, as well as developing treatments for these diseases, including the development of drugs and peptides as medications and gene therapies based on CRISPR/Cas9.
We have used an array of techniques to achieve this goal. A few examples are hiPSC disease models, mouse genetic approaches including transgenic and knockout mice, in utero electroporation, time-lapse live imaging of culture neurons and on brain slices, GRAPHIC technique for neural connectivity, FingR technique for synapse formation, as well as calcium imaging in primary neurons and on brain slices.
Neuronal Morphogenesis - Methods and ProtocolsRecent Updates
10/7/2024: We are pleased to welcome Lilit Drak, a MD candidate at Drexel University, to our lab.
9/5/2024: We are pleased to welcome Emily Taylor, an undergraduate volunteer, to our lab.
8/29/2024: Samridhi Sudan, an undergrad lab member & STAR Scholar, presented a poster at the Drexel STAR Scholars Summer Showcase.
8/17/2024: A book on neuronal morphogenesis has recently been published.
Neuronal Morphogenesis - Methods and Protocols
7/10/2024: The photos from the lab meeting have been uploaded.
7/8/2024: The photos from the lab meeting have been uploaded.
5/22/2024: We are pleased to welcome Diane Kim, an MS candidate at Drexel University, to our lab.
4/2/2024: Congratulations to Vasu, MD student, on getting a fellowship for his summer research about YWHAG(14-3-3gamma) mutation disease.
3/4/2024: We are pleased to welcome Samridhi Sudan, STAR scholar, to our lab.
2/27/2024: Congratulations to Bill Telfer, MD student, on getting a fellowship for his summer research about ADNP syndrome/ASD.
1/18/2024: We are pleased to welcome Shiena Watanabe, MD, a research intern, to our lab.
1/12/2024: We are pleased to welcome Vasu, MD student at Drexel, to our lab.
1/10/2024: We are pleased to welcome Laasya Reddy Pesaladinne, a high school student intern, to our lab.
1/9/2024: We are pleased to welcome Vicky Shih, MD-PhD student at Drexel, to our lab.
1/8/2024: We are pleased to welcome Maurice Lindner-Jackson, PhD candidate in the Neuroscience program, to our lab.
1/5/2024: We are pleased to welcome William R. Telfer, MD student at Drexel, to our lab.
9/5/2024: We are pleased to welcome Emily Taylor, an undergraduate volunteer, to our lab.
8/29/2024: Samridhi Sudan, an undergrad lab member & STAR Scholar, presented a poster at the Drexel STAR Scholars Summer Showcase.
8/17/2024: A book on neuronal morphogenesis has recently been published.
Neuronal Morphogenesis - Methods and Protocols
7/10/2024: The photos from the lab meeting have been uploaded.
7/8/2024: The photos from the lab meeting have been uploaded.
5/22/2024: We are pleased to welcome Diane Kim, an MS candidate at Drexel University, to our lab.
4/2/2024: Congratulations to Vasu, MD student, on getting a fellowship for his summer research about YWHAG(14-3-3gamma) mutation disease.
3/4/2024: We are pleased to welcome Samridhi Sudan, STAR scholar, to our lab.
2/27/2024: Congratulations to Bill Telfer, MD student, on getting a fellowship for his summer research about ADNP syndrome/ASD.
1/18/2024: We are pleased to welcome Shiena Watanabe, MD, a research intern, to our lab.
1/12/2024: We are pleased to welcome Vasu, MD student at Drexel, to our lab.
1/10/2024: We are pleased to welcome Laasya Reddy Pesaladinne, a high school student intern, to our lab.
1/9/2024: We are pleased to welcome Vicky Shih, MD-PhD student at Drexel, to our lab.
1/8/2024: We are pleased to welcome Maurice Lindner-Jackson, PhD candidate in the Neuroscience program, to our lab.
1/5/2024: We are pleased to welcome William R. Telfer, MD student at Drexel, to our lab.
Publications
Neuronal Morphogenesis - Methods and Protocols
Kazuhito Toyooka (Editor & author)
Methods in Molecular Biology, Neuronal Morphogenesis - Methods and Protocols, Springer, 2024
Localization of activity-dependent neuroprotective protein (ADNP) in neurospheres
Sarah A. Bennison, Sara M. Blazejewski, Xiaonan Liu, Gal Hacohen-Kleiman, Shlomo Sragovich, Sofia Zoidou, Olga Touloumi, Nikolaos Grigoriadis, Illana Gozes, Kazuhito Toyo-oka
Molecular Psychiatry, vol. 28(5), 2023, p. 1829
Sarah A. Bennison, Sara M. Blazejewski, Xiaonan Liu, Gal Hacohen-Kleiman, Shlomo Sragovich, Sofia Zoidou, Olga Touloumi, Nikolaos Grigoriadis, Illana Gozes, Kazuhito Toyo-oka
Molecular Psychiatry, vol. 28(5), 2023, pp. 1946-1959
KIFC1 regulates the trajectory of neuronal migration.
H. Muralidharan, Shrobona Guha, Kiran Madugula, Ankita Patil, Sarah A. Bennison, Xiaohuan Sun, K. Toyo-oka, P. Baas
Journal of Neuroscience, vol. 42(11), 2022, pp. 2149-2165
Megan R. Radler, Xiaonan Liu, Megan Peng, Brenna Doyle, Kazuhito Toyo-Oka, Elias T. Spiliotis
Current Biology, 2022, In Press
Nuak kinase signaling in development and disease of the central nervous system
Sarah A. Bennison, Xiaonan Liu, Kazuhito Toyo-oka
Cellular Signaling, 2022, In Press
Sara M. Blazejewski, Sarah A. Bennison, Ngoc T. Ha, Xiaonan Liu, Trevor H. Smith, K. Dougherty, K. Toyo-oka
Cerebral cortex, vol. 32(4), 2022, pp. 770-795
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