Welcome to Toyooka Lab ‚Äď Autism Translational Research


ūüö©

 ******* Attention *******

We are seeking lab members, especially those with experience in behavioral tests in rodents. If you are interested in our research project, feel free to contact me (Kazuhito Toyooka at Contact Form or [email protected]).¬†

Thank you for visiting the website of the Toyooka Lab at Drexel University College of Medicine in Philadelphia.

Our team studies the molecular and cellular mechanisms underlying healthy cortical development. Current research focuses on identifying genes involved in neuronal morphogenesis, including neurite and spine formation and neural connectivity, as well as the etiology of neurodevelopmental disorders, such as autism spectrum disorder (ASD) and 17p13.3 deletion/duplication syndromes.

We have used an array of techniques to achieve this goal. A few examples are in utero electroporation, time-lapse live imaging of culture neurons and on brain slices, mouse genetic approaches including transgenic and knockout mice, GRAPHIC technique for neural connectivity, FingR technique for synapse formation, as well as calcium imaging. 

Cameron, Happy Birthday!
Cameron, Happy Birthday!

Recent Updates

7/10/2024:  The photos from the lab meeting have been uploaded.

7/8/2024: The photos from the lab meeting have been uploaded.

5/22/2024:  We are pleased to welcome  Diane Kim, an MS candidate at Drexel University, to our lab. 

4/2/2024:  Congratulations to Vasu Kansagra, MD student, on getting a fellowship for his summer research about YWHAG(14-3-3gamma) mutation disease. 

3/4/2024:   We are pleased to welcome  Samridhi Sudan, STAR scholar, to our lab. 

2/27/2024:  Congratulations to Bill Telfer, MD student, on getting a fellowship for his summer research about ADNP syndrome/ASD.

1/18/2024:   We are pleased to welcome  Shiena Watanabe, MD,  a research intern, to our lab.   

1/12/2024:   We are pleased to welcome  Vasu Kansagra,  MD student at Drexel, to our lab.   

1/10/2024:   We are pleased to welcome   Laasya Reddy Pesaladinne,  a high school student intern, to our lab.     

1/9/2024:   We are pleased to welcome  Vicky Shih,  MD-PhD student at Drexel, to our lab.   

1/8/2024:   We are pleased to welcome  Maurice Lindner-Jackson,  PhD candidate in the Neuroscience program, to our lab.

1/5/2024:   We are pleased to welcome  William R. Telfer,  MD student at Drexel, to our lab.   
 
11/02/2023: My undergraduate student, Bijaya Manandhar, presented her poster at Drexel Discovery Day 2023 today.

10/18/2023:   We are pleased to welcome Kendra Williams,  PhD candidate in the MCBG program, to our lab.
 
10/13/2023: An image of the ADNP protein from our previous publication has been selected and published in the current issue of Molecular Psychiatry.

9/29/2023: We had a fun pizza lunch for a lab member's birthday. Cameron, Happy Birthday!

9/19/2023:   We are pleased to welcome Sierra Coleman,  PhD candidate in the Neuroscience program, to our lab. 

9/1/2023:   We are pleased to welcome Sara Shigambayeva, an undergraduate student at Drexel, to our lab.   

8/31/2023: Undergrad lab member & STAR Scholar, Carrie Gordon, presented a poster at the Drexel STAR Scholars Summer Showcase.

8/31/2023: Undergrad lab member & STAR Scholar, Bijaya Manandhar, presented a poster at the Drexel STAR Scholars Summer Showcase. She worked at Dr. Elefant Lab, Biology Department, as a STAR Scholar.

8/30/2023:  A welcome dinner for Bijaya Manandhar, Carrie Gordon, Jiwoo Lee, and Cameron Anderson. Photos were uploaded to the Team.   

8/24/2023:  We went to a farewell dinner for Xiaonan Liu, a graduate student. Photos were uploaded.

8/17/2023:   We are pleased to welcome Cameron Anderson, PhD candidate in the Neuroscience program, to our lab. 

8/14/2023:  We are pleased to welcome Jiwoo Lee, a high school student intern, to our lab.   

Publications


Localization of activity-dependent neuroprotective protein (ADNP) in neurospheres


Sarah A. Bennison, Sara M. Blazejewski, Xiaonan Liu, Gal Hacohen-Kleiman, Shlomo Sragovich, Sofia Zoidou, Olga Touloumi, Nikolaos Grigoriadis, Illana Gozes, Kazuhito Toyo-oka

Molecular Psychiatry, vol. 28(5), 2023, p. 1829


The cytoplasmic localization of ADNP through 14-3-3 promotes sex-dependent neuronal morphogenesis, cortical connectivity, and calcium signaling


Sarah A. Bennison, Sara M. Blazejewski, Xiaonan Liu, Gal Hacohen-Kleiman, Shlomo Sragovich, Sofia Zoidou, Olga Touloumi, Nikolaos Grigoriadis, Illana Gozes, Kazuhito Toyo-oka

Molecular Psychiatry, vol. 28(5), 2023, pp. 1946-1959


KIFC1 regulates the trajectory of neuronal migration.


H. Muralidharan, Shrobona Guha, Kiran Madugula, Ankita Patil, Sarah A. Bennison, Xiaohuan Sun, K. Toyo-oka, P. Baas

Journal of Neuroscience, vol. 42(11), 2022, pp. 2149-2165


Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia during neurite initiation


Megan R. Radler, Xiaonan Liu, Megan Peng, Brenna Doyle, Kazuhito Toyo-Oka, Elias T. Spiliotis

Current Biology, 2022, In Press


Nuak kinase signaling in development and disease of the central nervous system


Sarah A. Bennison, Xiaonan Liu, Kazuhito Toyo-oka

Cellular Signaling, 2022, In Press


Rpsa Signaling Regulates Cortical Neuronal Morphogenesis via Its Ligand, PEDF, and Plasma Membrane Interaction Partner, Itga6.


Sara M. Blazejewski, Sarah A. Bennison, Ngoc T. Ha, Xiaonan Liu, Trevor H. Smith, K. Dougherty, K. Toyo-oka

Cerebral cortex, vol. 32(4), 2022, pp. 770-795



View all



Follow this website


You need to create an Owlstown account to follow this website.


Sign up

Already an Owlstown member?

Log in